DNA binding and dispersion activities of titanium dioxide nanoparticles with UV/vis spectrophotometry, fluorescence spectroscopy and physicochemical analysis at physiological temperature
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- 作者：Suhani Patela ; suhanipalkhiwala@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Palak Patela ; palak608@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sachin B. Undreb ; sachincug@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shivani R. Pandyac ; shivpan02@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Man Singhb ; c ; mansingh50@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Sonal Bakshia ; sonal.bakshi@nirmauni.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：TiO2 nanoparticles ; Dispersion activities ; DNA binding ; Intermolecular interaction ; In vitro assessment of genotoxicity ; Bioavailability
- 刊名：Journal of Molecular Liquids
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：213
- 期：Complete
- 页码：304-311
- 全文大小：674 K
文摘
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Survismeter has been used to study physicochemical properties of TiO2 NPs.
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TiO2 NPs are found to be mono dispersed in biological culture media.
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Assessment of DNA-NP interaction is done and mechanism is proposed.
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Hyperchromism observed in UV–visible studies indicates electrostatic interaction.
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Quenching of EtBr fluorescence suggests intercalation of TiO2 NPs in DNA.