Effect of increasing alkyl chain of 1st tier dendrimers on binding and release activities of methotrexate drug: An in vitro study
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- 作者：Reena Tondwal reenatondwal@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Man Singh ; mansingh50@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dendrimers ; Drug carrier ; In vitro release ; Alkyl chain ; UV&ndash ; vis ; Controlled release
- 刊名：Journal of Molecular Liquids
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：211
- 期：Complete
- 页码：466-475
- 全文大小：2399 K
文摘
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Synthesis of TTDMM, TTDEM and TTDPM dendrimers and their binding complexes with MTX as drug delivery system
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Characterization of complexes with FTIR, DLS and SEM
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TTDPM encapsulates maximum MTX.
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260, 305 and 375 nm λmax with MTX and its complexes depict MTX
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51.47%/10 h MTX release proves TTDPM as sustainable vehicle.