Differential regulation of monocytic expression of leukotriene and lipoxin receptors
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- 作者：Marcelo Heron Petri ; marcelo.petri@ki.se" class="auth_mail" title="E-mail the corresponding author ; Silke Thul ; Olga Ovchinnikova ; Magnus Bä ; ck
- 关键词：Eicosanoids ; Inflammation ; Leukotriene ; Lipoxin ; Lipoxygenase ; Monocyte ; Resolution of inflammation
- 刊名：Prostaglandins and Other Lipid Mediators
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：121
- 期：part_PA
- 页码：138-143
- 全文大小：767 K
文摘
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Activated CD4+ cells up-regulated FPR2/ALX receptor, but not BLT1 receptor mRNA in human macrophages.
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IFN-γ and supernatants from activated CD4+ cells up-regulated FPR2/ALX mRNA and protein levels in THP-1 cells.
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FPR2/ALX receptor up-regulation in monocytes and THP-1 cells was mainly intracellular.
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LXA4 reduced mRNA levels of pro inflammatory mediators in THP-1 cells.
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This differential regulation of expression for lipid mediator receptor in macrophages may be of importance in lymphocyte-driven inflammation.