Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists
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- 作者：Ioana Intaa ; b ; Emese Domonkosb ; c ; Natascha Pfeifferb ; Rolf Sprengeld ; Markus Bettendorfa ; Undine E. Lange ; Dragos Intab ; e ; 1 ; Dragos.Inta@zi-mannheim.de" class="auth_mail" title="E-mail the corresponding author ; Peter Gassb ; 1
- 关键词：MK-801 ; Puberty ; Dentate gyrus ; Cortex ; Gender ; GluN2B
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：181-187
- 全文大小：1480 K
文摘
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The brain activation pattern induced by NMDAR blockade during puberty is unknown.
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We found high hippocampal c-Fos activation by MK-801 at postnatal day 24.
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Cortical MK-801-induced activation changed from deep to all layers during puberty.
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GluN2B-specific antagonists triggered activation patterns distinct from MK-801.