Bioactivity of sol-gel-derived TiO₂ coating on polyetheretherketone: In vitro and in vivo studies

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• 作者：Takayoshi Shimizu^a ; ^{takayosh@kuhp.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Shunsuke Fujibayashi^a ; Seiji Yamaguchi^b ; Koji Yamamoto^c ; Bungo Otsuki^a ; Mitsuru Takemoto^a ; Masako Tsukanaka^a ; Takashi Kizuki^b ; Tomiharu Matsushita^b ; Tadashi Kokubo^b ; Shuichi Matsuda^a
• 关键词：PEEK ; Bioactivity ; TiO2 ; Sol&ndash ; gel ; Sandblast ; O2 plasma
• 刊名：Acta Biomaterialia
• 出版年：2016
• 出版时间：15 April 2016
• 年：2016
• 卷：35
• 期：Complete
• 页码：305-317
• 全文大小：4105 K

文摘

A polyetheretherketone (PEEK) surface was modified using a sol–gel-derived TiO₂ coating in order to confer bone-bonding ability. To enhance the bonding strength of the coating layer, pretreatment with either O₂ plasma or sandblasting was performed prior to sol–gel coating. Additionally, post-treatment with acid was carried out to confer apatite (calcium phosphate)-forming ability to the surface. Biomechanical and histological analyses performed using an in vivo rabbit tibia model showed that PEEK surfaces modified with sol–gel-derived TiO₂ and acid post-treatment had better bone-bonding properties than uncoated PEEK surfaces. These modified surfaces also performed well in terms of their in vitro cell responses due to their modified surface chemistries and topographies. Although O₂ plasma or sandblasting treatment were, for the most part, equivocal in terms of performance, we conclude that sol–gel-derived TiO₂ coating followed by acid post-treatment significantly improves the bone bonding ability of PEEK surfaces, thus rendering them optimal for their use in surgical implants.

Statement of Significance

The role of polyetheretherketone (PEEK) as an alternative biomaterial to conventional metallic implant materials has become increasingly important. However, its low bone bonding ability is yet to be resolved. This in vivo and in vitro investigation on the functionalization of PEEK surfaces highlights the utility of this material in clinical interventions that require implants, and may extend range of applications of PEEK.