Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice
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- 作者：Yui Yamashitaa ; yui_y@kuhp.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Nobuko Yamada-Gotob ; nyamadagoto@keio.jp" class="auth_mail" title="E-mail the corresponding author ; Goro Katsuuraa ; Yukari Ochia ; Yugo Kanaia ; Yuri Miyazakic ; Koichiro Kuwaharad ; Naotetsu Kanamotoa ; Masako Miuraa ; Akihiro Yasodaa ; Kousaku Ohinatac ; Nobuya Inagakia ; Kazuwa Nakaoe
- 关键词：CNP ; c-type natriuretic peptide ; NPR-B ; natriuretic peptide receptor-B ; BND mice ; mice with brain-specific NPR-B deletion ; SD ; standard diet ; HFD ; high-fat diet
- 刊名：Peptides
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：81
- 期：Complete
- 页码：38-50
- 全文大小：3954 K
文摘
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We generated mice with brain-specific NPR-B deletion (BND mice).
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BND mice are resistant to high-fat diet (HFD)-induced obesity.
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BND mice are protected against the development of HFD-induced hepatic steatosis.
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BND mice are protected against HFD-induced lipid accumulation in the mesenteric fat.