Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway
详细信息 查看全文
- 作者：Miao Hea ; hemiao@mail.cmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Takamichi Ichinoseb ; ichinose@oita-nhs.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yuan Songc ; Yasuhiro Yoshidac ; Kanae Bekkid ; Keiichi Arashidanic ; Seiichi Yoshidab ; Masataka Nishikawae ; Hirohisa Takanof ; Takayuki Shibamotog ; Guifan Suna
- 关键词：Desert dust ; TLR deficiency ; MyD88 deficiency ; Asthma
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：296
- 期：Complete
- 页码：61-72
- 全文大小：2076 K
文摘
- class="listitem" id="list_l0005">
- class="label">•
ASD enhanced Th2 response in TLR2−/−, TLR4−/− and WT mice, but not in MyD88−/−.
- class="label">•
Th2 responses in TLR2−/− mice were attenuated by LPS inhibitor polymyxin B.
- class="label">•
TLR2 and TLR4 signaling is important in allergic lung disease aggravation by ASD.
- class="label">•
MyD88 is the key adapter molecule in the signaling pathway for Th2 activation.
- class="label">•
ASD-bound LPS and β-glucan may be strong candidates for the aggravating substances.