Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung
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- 作者：Masahito Naito ; MDa ; b ; d ; Keiju Aokage ; MD PhDa ; Kouichi Saruwatari ; MDa ; c ; Kakeru Hisakane ; MDa ; c ; Tomohiro Miyoshi ; MDb ; Tomoyuki Hishida ; MD PhDb ; Junji Yoshida ; MD PhDb ; Sugano Masato ; MD PhDa ; Motohiro Kojima ; MD PhDa ; Takeshi Kuwata ; MD PhDa ; Satoshi Fujii ; MD PhDa ; Atsushi Ochiai ; MD PhDa ; Yukitoshi Sato ; MD PhDd ; Masahiro Tsuboi ; MD PhDb ; Genichiro Ishii ; MD PhDa ; gishii@east.ncc.go.jp" class="auth_mail" title="E-mail the corresponding author ; ishii691@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adenocarcinoma in situ ; Minimally invasive adenocarcinoma ; Lepidic predominant lung adenocarcinoma ; Stepwise progression ; Tumor microenvironment
- 刊名：Lung Cancer
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：53-62
- 全文大小：4540 K
文摘
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The cancer cells and stromal cells are immunostained in LPA.
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Invasive potential of cancer cells is increased in noninvasive component of MIA.
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At the progression from MIA to LPA-S, microenvironmental molecular changes occur.