Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor
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- 作者：Masutaka Furuea ; b ; c ; furue@dermatol.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Gaku Tsujia ; b ; Chikage Mitomaa ; b ; Takeshi Nakaharaa ; c ; Takahito Chibaa ; Saori Morino-Kogab ; d ; Hiroshi Uchia
- 关键词：AHR ; aryl hydrocarbon receptor ; CYP1A1 ; cytochrome P450 1A1 ; EDC ; epidermal differentiation complex ; FICZ ; 6-formylindolo[3.2-b]carbazole ; ICZ ; indolo[3.2-b]carbazole ; NRF2 ; nuclear factor-erythroid 2-related factor-2 ; TCDD ; 2.3.7.8-tetrachlorodibenzo-p-dioxin
- 刊名：Journal of Dermatological Science
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：80
- 期：2
- 页码：83-88
- 全文大小：661 K
文摘
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Aryl hydrocarbon receptor (AHR) is a sensor for low molecular weight chemicals.
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Ligand activation of AHR induces gene expression of filaggrin.
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Dioxins and antioxidant phytochemicals are AHR ligands.
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Both oxidative and antioxidant ligands induce gene expression of filaggrin.