period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection
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- 作者：Victoria W. Allen1 ; Reed M. O&rsquo ; Connor1 ; 4 ; Matthew Ulgherait1 ; 4 ; Clarice G. Zhou1 ; Elizabeth F. Stone1 ; Vanessa M. Hill1 ; Keith R. Murphy2 ; Julie C. Canman3 ; William W. Ja2 ; Mimi M. Shirasu-Hiza1 ; ms4095@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：infection ; tolerance ; resistance ; immunity ; Drosophila ; Burkholderia cepacia ; circadian ; period mutant ; feeding ; diet ; glucose ; amino acids ; TOR ; TORC1 ; TORC2 ; Rictor
- 刊名：Current Biology
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：26
- 期：2
- 页码：184-194
- 全文大小：2147 K
文摘
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Circadian per mutants have increased feeding and increased tolerance of B. cepacia
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Both dietary glucose and amino acids contribute to host tolerance of B. cepacia
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Loss of Drosophila TORC1 decreases resistance against B. cepacia
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In contrast to dTORC1, dTORC2 inhibits both resistance and tolerance