The inhibitory effect of disulfiram encapsulated PLGA NPs on tumor growth: Different administration routes
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- 作者：Hamidreza Faseheea ; Ghazaleh Zarrinradb ; Seyed Mohammad Tavangarc ; Seyed Hamidollah Ghaffarib ; Shghaffari200@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Shahab Faghihia ; sfaghihi@nigeb.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Shahabeddin.faghihi@mail.mcgill.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：PLGA nanoparticles ; Disulfiram delivery ; Administration route ; Breast cancer ; MCF7 cells
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：63
- 期：Complete
- 页码：587-595
- 全文大小：1913 K
文摘
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A new delivery system for delivery of disulfiram into breast cancer cells is proposed.
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The encapsulated disulfiram shows higher activity in apoptosis induction compared to free drug.
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The encapsulated disulfiram shows significant cytotoxicity against breast cancer cells both in vitro and in vivo.
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Different administration routes including intra-venous, intra-tumoral and intra-peritoneal are investigated.
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The intravenous route is more efficient in suppressing tumor growth compared to other routes of administration.