Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis
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- 作者：Tiffany C. Blaira ; tiffany.blair@agonox.com" class="auth_mail" title="E-mail the corresponding author ; Minsha Manoharana ; manohara@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Stephanie D. Rawlings-Rheaa ; srawlingsd@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ian Taggeb ; taggei@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Steven G. Kohamac ; kohamas@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Julie Hollister-Smithc ; Hollister-smith@comcast.net" class="auth_mail" title="E-mail the corresponding author ; Betsy Fergusonc ; fergusob@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Randall L. Woltjerd ; woltjerr@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Meredith C. Fredericke ; frederim@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; James Pollarob ; jim.pollaro@gmail.com" class="auth_mail" title="E-mail the corresponding author ; William D. Rooneyb ; rooneyw@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Larry S. Shermanc ; shermanl@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Dennis N. Bourdettee ; bourdette@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Scott W. Wonga ; f ; wongs@ohsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Magnetic resonance imaging (MRI) ; Inflammatory ; Demyelination ; Interleukin 17 (IL-17) ; Th1 ; Th17 ; Intrathecal IgG
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：291
- 期：Complete
- 页码：1-10
- 全文大小：1917 K
文摘
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Animals with JME display inflammatory demyelinating condition.
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Active demyelination observed in 10 of 12 JME animals
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Demyelinating lesions express pro-inflammatory cytokine, IL-17
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Infiltrating T cells in lesions display Th1 and Th17 phenotypes.
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JME animals have elevated CSF IgG index and/or 2 or more OCBs.