Effects of Tongxinluo on myocardial fibrosis in diabetic rats

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• 作者：Xiaomei Wang^a ; ^b ; Changzheng Mu^c ; Tianchi Mu^c ; Lili Gao^b ; Yaxue Zhao^b ; Yangyi Zhang^b ; Zhimian Zhang^a ; ^{zhimianzhang@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：diabetic myocardial fibrosis ; Smad3 ; Smad7 ; Tongxinluo ; transforming growth factor beta 1
• 刊名：Journal of the Chinese Medical Association
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：79
• 期：3
• 页码：130-136
• 全文大小：934 K

文摘

The aim of this study was to explore the effect of Tongxinluo on myocardial fibrosis in diabetic rats and its possible mechanism of action.

Methods

Diabetic rat models were established and then divided into three groups: control, diabetes, and Tongxinluo groups. Heart function and myocardial interstitial collagen volume fraction were investigated, and the protein and mRNA expression levels of transforming growth factor beta 1 (TGF-β₁), Smad₃, and Smad₇ were measured.

Results

Heart function was clearly abnormal in the diabetes group compared with that in the control group, and the collagen volume fraction and mRNA expression levels of TGF-β₁ and Smad₃ were higher. However, the protein and mRNA expression levels of Smad₇ were lower. In the Tongxinluo group, it was observed that these indicators were improved.

Conclusion

Tongxinluo was effective for the prevention and treatment of myocardial fibrosis in diabetic rats. It probably mediates the expressions of TGF-β₁, Smad₃, and Smad₇ in rat cardiomyocytes to reduce the occurrence of myocardial fibrosis in diabetic rats.