Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin
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- 作者：Yelko Rodrí ; guez-Carrascoa ; Daniela Heilosb ; c ; d ; Lennart Richterf ; Roderich D. Sü ; ssmuthf ; Petra Heffeterc ; d ; e ; Michael Sulyokg ; Lukas Kennerh ; i ; j ; Walter Bergerc ; d ; e ; walter.berger@meduniwien.ac.at" class="auth_mail" title="E-mail the corresponding author ; Rita Dornetshuber-Fleissb ; c ; d ; rita.dornetshuber@univie.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABC ; ATP-binding cassette ; Bea ; beauvericin ; b.w. ; bodyweight ; DMSO ; dimethyl sulfoxide ; Enn ; Enniatin ; ESI ; Electrospray ionisation ; LC-MS/MS ; liquid chromatography-tandem mass spectrometry ; p.a. ; per analysis ; sSRM ; scheduled selected reaction monitoring ; SSE ; signal enhancement or suppression ; LODs ; limits of detection ; LOQs ; limits of quantitation ; RSDr ; relative standard deviation ; SCID ; severe combined immunodeficiency
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：247
- 期：Complete
- 页码：35-44
- 全文大小：2039 K
文摘
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Development of a LC–MS/MS method for Enn B and Bea quantification in mice tissue.
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Nine days i.p. treatment of Enn B or Bea showed no systemic toxicity in mice.
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Contribution of hepatic/intestinal metabolism for Enn B but not Bea was suggested.
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Both substances showed distinct tissue accumulation with Bea being more potent.
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Tumor accumulation of Enn B and Bea emphasizes their anticancer potential