Transcranial functional ultrasound imaging of the brain using microbubble-enhanced ultrasensitive Doppler
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- 作者：Claudia Erricoa ; b ; c ; Bruno-Fé ; lix Osmanskia ; b ; c ; Sophie Pezetd ; e ; Olivier Couturea ; b ; c ; Zsolt Lenkeid ; e ; 1 ; Mickael Tantera ; b ; c ; 1 ; Mickael.Tanter@espci.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Transcranial ; Functional ultrasound imaging ; Microbubbles ; Primary sensory cortex ; Blood volume ; Somatosensory activation
- 刊名：NeuroImage
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：124
- 期：part_PA
- 页码：752-761
- 全文大小：1548 K
文摘
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We combined ultrafast sensitive Doppler with contrast-enhanced ultrasound imaging.
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We retrieved highly-resolved neurovascular transcranial maps with contrast agents.
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The presence of microbubbles compensates for the attenuation from the skull.
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fUS is sensitive to the local hyperemia in the rat brain through the skull with microbubbles.
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Transcranial fUS imaging allows non-invasive functional brain studies in rodents.