Recombinant chicken interferon-alpha inhibits the replication of exogenous avian leukosis virus (ALV) in DF-1 cells
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- 作者：Manman Daia ; b ; c ; d ; daimanman1229@163.com" class="auth_mail" title="E-mail the corresponding author ; Siyu Wua ; b ; c ; d ; 15813365538@163.com" class="auth_mail" title="E-mail the corresponding author ; Min Fenga ; b ; c ; d ; hunanfengmin@163.com" class="auth_mail" title="E-mail the corresponding author ; Saixiang Fenga ; b ; c ; d ; squarefeng@126.com" class="auth_mail" title="E-mail the corresponding author ; Chao Sune ; chaosun86@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Dayong Baie ; bdy2006@163.com" class="auth_mail" title="E-mail the corresponding author ; Mingzhu Gue ; gumingzhu2008@163.com" class="auth_mail" title="E-mail the corresponding author ; Ming Liaoa ; b ; c ; d ; mliao@scau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Weisheng Caoa ; b ; c ; d ; caoweish@scau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALV ; avian leukosis virus ; ALV-A/B/J ; avian leukosis virus subgroup A/B/J ; ChIFNα ; chicken interferon alpha ; ChIRF-3 ; chicken IFN regulatory factor 3
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：62-69
- 全文大小：1571 K
文摘
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This study firstly reported that ALV-J could induce a mixed Th1/Th2 cytokine response by elevating levels of both interleukin-2 (IL-2) and IL-10 during the late stages of ALV-J infection in vivo.
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This study firstly reported that different ALV subgroups or strains up-regulated chicken IFN regulatory factor 3 (ChIRF-3) promoter activity, suggesting that ALV infection could trigger Type I IFNs pathway in vitro.
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This study firstly reported that ChIFNα restrained ALV replication as measured by decreases in viral protein p27 levels and mRNA expression.