Freezing of gait in early Parkinson's disease: Nigral iron content estimated from magnetic resonance imaging
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- 作者：Marguerite Wielera ; Myrlene Geeb ; Richard Camiciolia ; W.R. Wayne Martina ; wmartin@ualberta.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson's disease ; MRI ; Iron ; Freezing ; Gait ; Midbrain
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：361
- 期：Complete
- 页码：87-91
- 全文大小：217 K
文摘
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- class="label">•
freezing of gait occurs commonly in association with disease progression even in early Parkinson's disease
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increased severity of motor symptomatology at baseline is predictive of the development of freezing
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changes in motor score correlate with changes in R2* in lateral substantia nigra compacta suggesting increased iron
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individuals who develop freezing have a greater change in SNc iron content (R2*) over time than those who do not