HIV-Tat induces a decrease in IKr and IKs via reduction in phosphatidylinositol-(4,5)-bisphosphate availability
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- 作者：Zeineb Es-Salah-Lamoureuxa ; 1 ; Mariam Jounia ; 1 ; Olfat A. Malaka ; Nadjet Belbachira ; Zeina Reda Al Sayeda ; Marine Gandon-Renarda ; Guillaume Lamiraultb ; Chantal Gauthiera ; Isabelle Baró ; a ; Flavien Charpentierb ; Kazem Zibarac ; Patricia Lemarchandb ; Bruno Beaumelled ; Nathalie Gaborita ; 1 ; nathalie.gaborit@univ-nantes.fr" class="auth_mail" title="E-mail the corresponding author ; Gildas Loussouarna ; 1
- 关键词：IKr ; IKs ; Phosphatidylinositol-(4 ; 5)-bisphosphate ; HIV-Tat protein ; Induced pluripotent stem cell-derived cardiomyocytes ; Long QT syndrome
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：1-13
- 全文大小：4923 K
文摘
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HIV-Tat protein decreases several cardiac currents.
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HIV-Tat protein acts on the currents by sequestering PIP2.
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HIV-Tat prolongs ventricular action potentials in human iPS-derived cardiomyocytes.
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Tat-induced reduction in PIP2 may explain QT prolongation in HIV-infected patients.