A relevant exposure to a food matrix contaminated environmentally by polychlorinated biphenyls induces liver and brain disruption in rats
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- 作者：Fayç ; al Ounnasa ; b ; faycal.ounnas@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author ; Florence Privé ; a ; b ; florenceprive@yahoo.fr" class="auth_mail" title="E-mail the corresponding author ; Fré ; deric Lamarchea ; frederic.lamarche@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author ; Patricia Salenb ; patricia.salen@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author ; Isabelle Favier-Hiningera ; isabelle.hininger@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author ; Philippe Marchandc ; philippe.marchand@oniris-nantes.fr" class="auth_mail" title="E-mail the corresponding author ; Bruno Le Bizecc ; bruno.lebizec@oniris-nantes.fr" class="auth_mail" title="E-mail the corresponding author ; Anais Venisseauc ; anais.venisseau@oniris-nantes.fr" class="auth_mail" title="E-mail the corresponding author ; Cé ; cile Batandiera ; cecile.batandier@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author ; Eric Fontainea ; d ; eric.fontaine@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author ; Michel de Lorgerilb ; michel.delorgeril@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author ; Christine Demeilliersa ; christine.demeilliers@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：PCBs ; Low dose ; Food matrix ; Mitochondria ; Oxidative stress
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：80-88
- 全文大小：493 K
文摘
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A relevant animal model (daily low dose, mixture of PCBs).
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A dietary environmentally PCBs contaminated matrix.
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At low doses, chronic PCBs exposure resulted in adverse effects in liver.
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At low doses, chronic PCBs exposure resulted in adverse effects in brain.
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Understanding on mechanisms of PCBs toxic effects which involve mitochondria.