Reduced striatal dopamine D_2/3 receptor availability in Body Dysmorphic Disorder

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• 作者：Nienke C. Vulink^a ; Robin S. Planting^a ; Martijn Figee^a ; Jan Booij^b ; Damiaan Denys^a ; ^c ; ^{ddenys@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Body Dysmorphic Disorder (BDD) ; Dopamine D2/3 receptor ; Obsessive Compulsive and Related Disorders (OCRD) ; Single Photon Emission Computed Tomography (SPECT)
• 刊名：European Neuropsychopharmacology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：26
• 期：2
• 页码：350-356
• 全文大小：515 K

文摘

Though the dopaminergic system is implicated in Obsessive Compulsive and Related Disorders (OCRD), the dopaminergic system has never been investigated in-vivo in Body Dysmorphic Disorder (BDD). In line with consistent findings of reduced striatal dopamine D_2/3 receptor availability in Obsessive Compulsive Disorder (OCD), we hypothesized that the dopamine D_2/3 receptor availability in the striatum will be lower in patients with BDD in comparison to healthy subjects.

Striatal dopamine D_2/3 receptor Binding Potential (BP_ND) was examined in 12 drug-free BDD patients and 12 control subjects pairwise matched by age, sex, and handedness using [¹²³I]iodobenzamide Single Photon Emission Computed Tomography (SPECT; bolus/constant infusion technique). Regions of interest were the caudate nucleus and the putamen. BP_ND was calculated as the ratio of specific striatal to binding in the occipital cortex (representing nonspecific binding).

Compared to controlsclass="boldFont">, dopamine D_2/3 receptor BP_ND was significantly lower in BDD, both in the putamen (pclass="boldFont">=0.017) and caudate nucleus (pclass="boldFont">=0.022).

This study provides the first evidence of a disturbed dopaminergic system in BDD patients. Although previously BDD was classified as a separate disorder (somatoform disorder), our findings give pathophysiological support for the recent reclassification of BDD to the OCRD in DSM-5.