Aorto-ostial atherosclerotic coronary artery disease—Risk factor profiles, demographic & angiographic features

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• 作者：S.K. Verma^a ; ^{ksunilverma02@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; B. Kumar^b ; ^{binay.kumar.mamc@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; V.K. Bahl^a ; ^{vkbahl2002@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Coronary artery disease ; Risk factors ; Aorto-ostial disease
• 刊名：IJC Heart & Vasculature
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：26-31
• 全文大小：943 K

文摘

The risk factors along with demographic and angiographic features associated with aorto-ostial atherosclerotic coronary artery disease usually differ from that of non-aorto-ostial atherosclerotic coronary artery disease.

Objectives

This study was designed to evaluate etiology of aorto-ostial atherosclerotic coronary artery disease involving left main coronary artery (LMCA), right coronary artery or both with consideration of clinical risk factors, demographic and angiographic features.

Methods

A total of 7356 angiograms over 2 years in continuation were analyzed.

Results

116 patients were found to have aorto-ostial coronary artery disease with prevalence of 1.5. A total of 95 patients who have complete data were analyzed. Mean age was 59 ± 10 years. Prevalence in males was 5.7 times greater than female. Isolated ostial LMCA was 2 times more prevalent than isolated ostial RCA. Hypertension, diabetes and smoking were the main risk factors. 34.7% of the patients had hypercholesterolemia (> 180 mg/dl) and 26.3% of the patients had hypertriglyceridemia (> 150 mg/dl). High TC/HDL (> 3.5) ratio was seen in 77.9% of the patients. When ostial LMCA group was compared with ostial RCA group hypertriglyceridemia (Odds ratio 9.8, 95% CI, 1.7–4.2, P < 0.001) and hypercholesterolemia (Odds ratio 7.05, 95% CI, 1.7–5.7, P < 0.001) emerged as independent risk factors for ostial LMCA disease.

Conclusion

Overall there is 1.5% prevalence of atherosclerotic aorto-ostial disease of coronary arteries among patients of atherosclerotic coronary artery disease and higher proportions of patients are of male sex. Hypercholesterolemia, hypertriglyceridemia and high TC/HDL ratio can be considered as risk factors for aorto-ostial atherosclerotic coronary artery disease.