Assessment of the genotoxic potential of two zinc oxide sources (amorphous and nanoparticles) using the in vitro micronucleus test and the in vivo wing somatic mutation and recombination test
详细信息 查看全文
- 作者：É ; rica de Melo Reisa ; Alexandre Azenha Alves de Rezendea ; Diego Vilela Santosa ; Pollyanna Francielli de Oliveriab ; Heloisa Diniz Nicolellab ; Denise Crispim Tavaresb ; Anielle Christine Almeida Silvac ; Noelio Oliveira Dantasc ; Má ; rio Antô ; nio Spanó ; a ; maspano@ufu.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Drosophila melanogaster ; Micronuclei ; Mutagenicity ; SMART ; V79 cells ; Homologous recombination
- 刊名：Food and Chemical Toxicology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：84
- 期：Complete
- 页码：55-63
- 全文大小：1201 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
ZnO NPs, in V79 cells, were toxic at concentrations equal to or higher than 240.0 μM.
- class="label">•
ZnO NPs, in V79 cells, were genotoxic at 120.0 μM but not cytotoxic.
- class="label">•
Amorphous ZnO and ZnO NPs were not mutagenic in the ST cross of SMART.
- class="label">•
In HB cross, ZnO (6.25 mM) and ZnO NPs (12.50 mM) increased mutant spots.
- class="label">•
Mutagenicity of ZnO may depend on the concentration, size and/or particle shape.