Synthesis and antiproliferative activity of D-ring substituted steroidal benzamidothiazoles
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- 作者：Ning-Juan Fana ; fannj1980@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qiu-Rui Heb ; Min Duana ; Yu-Bin Baib ; Jiang-Jiang Tangb ; tangjiang11@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Progesterone ; Thiazole ; Steroidal derivatives ; Antiproliferative activity
- 刊名：Steroids
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：112
- 期：Complete
- 页码：103-108
- 全文大小：389 K
文摘
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A series of novel D-ring substituted steroidal benzamidothiazoles were designed and synthesized.
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Antiproliferative activities of the newly synthesized derivatives were evaluated against two human cancer cell lines.
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Compounds class="boldFont">8b, class="boldFont">8d and class="boldFont">8g exhibited moderate antiproliferative activities against SKOV-3 cells.