Injectable LiNc-BuO loaded microspheres as in vivo EPR oxygen sensors after co-implantation with tumor cells
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- 作者：Juliane Franka ; 1 ; Daniel Gü ; ndelb ; 1 ; Simon Dreschera ; Oliver Thewsb ; oliver.thews@medizin.uni-halle.de" class="auth_mail" title="E-mail the corresponding author ; Karsten Mä ; dera ; karsten.maeder@pharmazie.uni-halle.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：AT1 ; Dunning R3227 AT-1 ; EPR ; electron paramagnetic resonance ; LDH ; lactate dehydrogenase ; LiNc-BuO ; lithium octa-n-butoxynaphthalocyanine ; MPs ; microparticles ; pO2 ; partial pressure of oxygen ; PVAc ; poly(vinyl acetate) ; W256 ; Walker-256
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：741-749
- 全文大小：3182 K
文摘
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We developed injectable and biocompatible microparticles for in vivo EPR oximetry.
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Co-implantation with tumor cells led to a homogeneous distribution in the tumor.
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Intratumoral pO2 values in two syngeneic rat tumors were assessed non-invasively.
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pO2 values were confirmed by fluoro-optical measurements and pimonidazole binding.