- 作者：Elisabetta Calore1 ; elisabetta.calore@unipd.it" class="auth_mail" title="E-mail the corresponding author ; Piero Marson2 ; Marta Pillon1 ; Manuela Tumino1 ; Tiziana Tison2 ; Chiara Mainardi1 ; Giustina De Silvestro2 ; Sara Rossin1 ; Genny Franceschetto1 ; Elisa Carraro1 ; Matilde Pescarin1 ; Stefania Varotto1 ; Roberta Destro1 ; Maria Vittoria Gazzola1 ; Giuseppe Basso1 ; Chiara Messina1
- 关键词：Extracorporeal photochemotherapy ; Acute graft-versus-host disease ; Hematopoietic stem cell transplantation ; Children
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：21
- 期：11
- 页码：1963-1972
- 全文大小：821 K
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We conducted a retrospective study of 72 consecutive pediatric patients treated with extracorporeal photochemotherapy/photopheresis for acute graft-versus-host disease.
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Twenty-one steroid-refractory, 21 steroid-dependent, and 30 patients with infectious complications were included.
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The infectious complications group included 9 with no steroids before extracorporeal photochemotherapy/photopheresis and 21 with steroids.
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Outcomes at the end of extracorporeal photochemotherapy/photopheresis were complete remission, 72%; transplantation-related mortality day +180, 4%; 5-year overall survival, 71%; time to progression, 81%; and progression-free survival, 72%.
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Extracorporeal photochemotherapy/photopheresis was highly effective in acute graft-versus-host disease without negative impact on primary disease.