In vitro angiotensin I converting enzyme inhibition by a peptide isolated from Chiropsalmus quadrigatus Haeckel (box jellyfish) venom hydrolysate
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- 作者：Pamela Berilyn T. Soa ; e ; sopamela23@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Peter Rubioa ; c ; Stephen Liriob ; Allan Patrick Macabeoa ; c ; f ; Hsi-Ya Huangb ; Mary Jho-Anne T. Corpuza ; c ; d ; Oliver B. Villafloresa ; c ; e ; oliver_7592@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chiropsalmus quadrigatus ; Box jellyfish ; ACE ; Hypertension ; Venom
- 刊名：Toxicon
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：77-83
- 全文大小：748 K
文摘
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Jellyfish venom extract (JVE) was prepared and subjected to successive pepsin and papain enzymatic hydrolysis.
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The sample was fractionated using SP-Sephadex G-25 and RP-HPLC chromatography to identify peptides inhibiting ACE activity.
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One peptide sequenced de novo using MALDI-TOF-MS, ACPGPNPGRP, has an IC50 of 2.03 μM.