Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice
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- 作者：Alexandra J. Mablya ; Wen Liua ; Jessica M. Mc Donalda ; Jean-Cosme Dodartb ; Fré ; dé ; rique Bardc ; Cynthia A. Lemered ; Brian O'Nuallaina ; Dominic M. Walsha ; dwalsh3@partners.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease ; Amyloid β-protein ; Immunotherapy ; Oligomers ; APP transgenic mice
- 刊名：Neurobiology of Disease
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：82
- 期：Complete
- 页码：372-384
- 全文大小：1373 K
文摘
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m266 caused a dramatic increase in blood and aqueous brain Aβ in J20 mice.
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1C22 increased the levels of free Aβ in blood and bound to parenchymal amyloid in J20 mice.
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Neither antibody attenuated cognitive deficits or altered brain Aβ oligomers in J20 mice.
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Anti-Aβ antibody treatment increased mortality in J20, but not PDAPP mice.
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The adverse side-effects and lack of engagement with Aβ oligomers are worrying.