Synthesis, characterization and cytotoxicity of glutathione- and PEG-glutathione-superparamagnetic iron oxide nanoparticles for nitric oxide delivery
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- 作者：M.C. Santos ; A.B. Seabra ; M.T. Pelegrino ; P.S. Haddad ; haddadps@gmail.com" class="auth_mail" title="E-mail the corresponding author ; haddad.paula@unifesp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Superparamagnetic iron oxide nanoparticles ; Nitric oxide ; Cytotoxicity ; Drug delivery ; Thiolated nanoparticles ; S-nitrosated nanoparticles
- 刊名：Applied Surface Science
- 出版年：2016
- 出版时间：30 March 2016
- 年：2016
- 卷：367
- 期：Complete
- 页码：26-35
- 全文大小：2436 K
文摘
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This study highlights the capping of SPIONs with GSH and PEG.
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The nanoparticles are superparamagnetic at room temperature.
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No cytotoxicity was observed for nanoparticles against normal and cancer cells.
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Thiol groups on the surface of nanoparticles were nitrosated yielding nitric oxide.