Diagnostic accuracy and clinical relevance of an inflammatory biomarker panel for sepsis in adult critically ill patients
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- 作者：Philippe R. Bauera ; bauer.philippe@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Rahul Kashyapa ; Kashyap.Rahul@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Stacy C. Leagueb ; League.Stacy@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; John G. Parka ; Park.John@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Darci R. Blockb ; Block.Darci@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Nikola A. Baumannb ; Baumann.Nikola@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Alicia Algeciras-Schimnichb ; AlgecirasSchimnich.Alicia@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Sarah M. Jenkinsc ; Jenkins.Sarah@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Carin Y. Smithc ; Smith.Carin@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Ognjen Gajica ; Gajic.Ognjen@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Roshini S. Abrahamb ; Abraham.Roshini@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：APACHE IV ; Acute Physiology and Chronic Health Evaluation IV score ; AUC ; Area Under the Curve ; CD45+ ALC ; Absolute lymphocyte count by flow cytometry ; CD64 ; Cluster of Differentiation 64 antigen ; CD163 ; Cluster of Differentiation 163 antigen ; CREST syndrome ; Limited scleroderma ; CRP ; C-Reactive Protein ; DOR ; Diagnostic Odds Ratio ; HLA-DR ; Human Leukocyte Antigen complex ; ICU ; Intensive Care Unit ; LR ; Likelihood Ratio ; NPV ; Negative Predictive Value ; PCT ; Procalcitonin ; PPV ; Positive Predictive V
- 刊名：Diagnostic Microbiology & Infectious Disease
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：84
- 期：2
- 页码：175-180
- 全文大小：403 K
文摘
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This was a prospective, single center, double blind observational study of diagnostic accuracy of an inflammatory and immune panel in sepsis.
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C-reactive protein, procalcitonin, and neutrophil CD64 individually accurately discriminated early sepsis and infection in the critically ill patients.
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The absolute lymphocyte count by flow cytometry (CD45+) and the frequency of monocytes expressing HLA-DR as well as HLA-DR expression on monocytes while significantly lower were not sufficiently good as discriminators for sepsis
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The combination of C-reactive protein, procalcitonin, and neutrophil CD64 improved the diagnostic accuracy of sepsis.