Naïve juvenile oysters were exposed to a microbial challenge plus to Alexandrium catenella.
Hemocyte responded to the microbial challenge alone (induced by cohabitation with field-exposed oysters).
These hemocyte responses were partially inhibited by A. catenella exposure.
Increased hemocyte mortality suggested either an immune strategy (apoptosis), or cytotoxicity.
Lower PST accumulation suggested alteration of feeding-related processes.