PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia
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- 作者：Edoardo Parrellaa ; edoardo.parrella@unibs.it" class="auth_mail" title="E-mail the corresponding author ; Vanessa Porrinia ; v.porrini@unibs.it" class="auth_mail" title="E-mail the corresponding author ; Rosa Iorioa ; rosa91i@hotmail.it" class="auth_mail" title="E-mail the corresponding author ; Marina Benaresea ; marina.benarese@unibs.it" class="auth_mail" title="E-mail the corresponding author ; Annamaria Lanzillottaa ; annamaria.lanzillotta@unibs.it" class="auth_mail" title="E-mail the corresponding author ; Mariana Motaa ; m.coelhodamota@unibs.it" class="auth_mail" title="E-mail the corresponding author ; Mariella Fuscoc ; mariella.fusco@epitech.it" class="auth_mail" title="E-mail the corresponding author ; Paolo Toninb ; paolo.tonin@ospedalesancamillo.net" class="auth_mail" title="E-mail the corresponding author ; PierFranco Spanoa ; b ; pierfranco.spano@unibs.it" class="auth_mail" title="E-mail the corresponding author ; Marina Pizzia ; b ; marina.pizzi@unibs.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's Disease ; BBB ; brain blood barrier ; CM ; conditioned medium ; CNS ; central nervous system ; DIV ; days in vitro ; DMSO ; dimethyl sulfoxide ; LDH ; lactate dehydrogenase ; MCs ; mast cells ; NAEs ; N-acylethanolamines ; NF-kB ; Nuclear factor-kB ; OGD ; oxygen and glucose deprivation ; PD ; Parkinson's Disease ; PEA ; palmitoylethanolamide ; PPARs ; Peroxisome proliferator-activated receptors ; SEM ; standard error of the mean ; TBI ; traumatic brain injury
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PA
- 页码：409-417
- 全文大小：867 K
文摘
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Mast cells release neurotoxic factors upon activation induced by oxygen and glucose deprivation (OGD).
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PEA and luteolin synergistically reduce neurotoxicity mediated by OGD-activated mast cells.
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PEA and luteolin promoted direct synergistic neuroprotection in neurons subjected to OGD.