Clostridium difficile flagella predominantly activate TLR5-linked NF-κB pathway in epithelial cells
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- 作者：Jameel Bataha ; Cé ; cile Denè ; ve-Larrazeta ; Pierre-Alain Jolivota ; Sarah Kuehneb ; Anne Collignona ; Jean-Christophe Marvauda ; Imad Kansaua ; imad.kansau@u-psud.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Clostridium difficile ; Flagella ; Flagellin ; TLR5 signaling ; NF-κB ; MAPK ; Innate immune response ; Pro-inflammatory cytokines
- 刊名：Anaerobe
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：116-124
- 全文大小：1046 K
文摘
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We used two cell line models to characterize Clostridium difficile flagellin-TLR5 signaling.
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C. difficile flagellin predominantly activates the NF-κB signaling pathway.
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MAPKs signaling pathways are also activated by C. difficile flagellin, but to a lesser degree.
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Transcriptomic studies provide new data concerning the committed effectors and cytokines induced by FliC-TL5 interaction.
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C. difficile flagellin elicits up-regulation of pro-inflammatory gene expression and pro-inflammatory cytokine synthesis.