The potential role of some phytochemicals in recognition of mitochondrial damage-associated molecular patterns
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- 作者：Malgorzata Pierzchalska ; m.pierzchalska@ur.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Maja Grabacka
- 关键词：ARE ; antioxidant response elements ; CMN ; curcumin ; DAMP ; damage-associated molecular patterns ; DAG ; diacyloglycerol ; fMLF ; formylated chemotactic peptide &ndash ; f-MetLeuPhe ; FPR ; formyl peptide receptor ; FPRL ; FPR-like protein ; GSH ; glutathione ; HMGB1 ; high mobility group box 1 ; HSP70 ; heat shock protein 70 ; IP3 ; inositol 1 ; 4 ; 5-trisphosphate ; ITC ; isothiocyanate ; KEAP1 ; Kelch like Ech-associated protein 1 ; LPS ; lipopolysaccharide ; mtDNA ; mitochondrial DNA ; mtDAMPs ; mitochondria-derived damage a
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：24-34
- 全文大小：651 K
文摘
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Fragments of mitochondria mediate the response to stress and trauma, modulate the onset of inflammation and cancer.
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Dietary phytochemicals have many possible molecular targets, including membrane receptors and signaling molecules.
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The activation of receptors mtDAMPs and downstream pathways could be compromised by isothiocyanates and curcumin