Clinical usefulness of autoantibodies to M-type phospholipase A2 receptor (PLA2R) for monitoring disease activity in idiopathic membranous nephropathy (IMN)
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- 作者：Antonella Radicea ; Radice.Antonella@sancarlo.mi.it" class="auth_mail" title="E-mail the corresponding author ; Barbara Trezzib ; c ; barbara.trezzi83@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Umberto Maggiored ; umberto_maggiore@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Francesca Pregnolatoe ; francesca.pregnolato@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Tiziana Stellatof ; tizistellato@tiscali.it" class="auth_mail" title="E-mail the corresponding author ; Pietro Napodanoc ; pietronapodano@virgilio.it" class="auth_mail" title="E-mail the corresponding author ; Davide Rollag ; davide.rolla@hsanmartino.it" class="auth_mail" title="E-mail the corresponding author ; Gianpaola Pesceh ; pescegpl@unige.it" class="auth_mail" title="E-mail the corresponding author ; Marco D'Amicoi ; marco.damico@hsacomo.org" class="auth_mail" title="E-mail the corresponding author ; Domenico Santoroj ; dsantoro@unime.it" class="auth_mail" title="E-mail the corresponding author ; Francesco Londrinok ; londrinofrancesco@libero.it" class="auth_mail" title="E-mail the corresponding author ; Federica Raveral ; federicaravera@yahoo.it" class="auth_mail" title="E-mail the corresponding author ; Giuseppe Ortisia ; ortisi.giuseppe@sancarlo.mi.it" class="auth_mail" title="E-mail the corresponding author ; Renato Alberto Sinicob ; c ; renatoalberto.sinico@fastwebnet.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phospholipase A2 receptor ; Autoantibody ; Membranous nephropathy ; Proteinuria ; Biomarker
- 刊名：Autoimmunity Reviews
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：15
- 期：2
- 页码：146-154
- 全文大小：773 K
文摘
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Antibodies against PLA2R are highly specific serological markers of IMN
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anti-PLA2R levels in IMN are associated with disease activity as measured by proteinuria and other biomarkers;
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positive PLA2R Ab status is linearly associated with proteinuria over time;
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the probability of halving proteinuria is significantly increased (6.5 times) after negativization of anti-PLA2R Abs;
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in IMN patients anti-PLA2R Ab serial measurements could help optimal timing and duration of the immunosuppressive therapy.