Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast
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- 作者：Matthieu Ré ; gnacqa ; 2 ; matthieu.regnacq@univ-poitiers.fr" class="auth_mail" title="E-mail the corresponding author ; Pierre Voisina ; 2 ; Yves Y. Serea ; 1 ; Bin Wana ; Venty M.S. Soerosoa ; Marianne Bernarda ; Nadine Camougrandb ; c ; Franç ; ois-Xavier Bernardd ; Christine Barraultd ; Thierry Bergè ; sa
- 关键词：Autophagy ; Fatty acid ; Fatty acid synthase ; Lipid droplets ; Rapamycin ; Saccharomyces cerevisiae
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 August 2016
- 年：2016
- 卷：477
- 期：1
- 页码：33-39
- 全文大小：1275 K
文摘
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Lipid droplets are not required for autophagy induced by rapamycin.
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Lipid droplets are required for nitrogen starvation-induced autophagy.
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Only nitrogen starvation stimulates lipid synthesis in cells lacking lipid droplets.
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This lipid accumulation precludes autophagy and correlates with tangled ER membranes.
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This phenotype can be reversed by controlled fatty acid supply.