New insights into transfusion-related iron toxicity: Implications for the oncologist
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- 作者：John B. Portera ; j.porter@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Theo de Witteb ; M. Domenica Cappellinic ; Norbert Gattermannd
- 关键词：Iron overload ; Myelodysplastic syndromes ; Hematopoietic stem cell transplantation ; Transfusion ; Chelation ; Oncogenesis ; Thalassemia ; Acute myeloid leukemia
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：261-271
- 全文大小：1326 K
文摘
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Transfusional iron overload and its consequences are increasingly recognized in MDS.
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Evidence suggests iron overload affects clonal evolution and progression to AML.
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Pre-existing iron overload can also influence HSCT outcomes.
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Appropriate monitoring of body iron levels can help reduce iron-related toxicity.
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Prevention of organ and bone marrow damage may improve clinical outcomes.