Management of radiation and chemotherapy related acute toxicity in gastrointestinal cancer

详细信息    查看全文

• 作者：Gerhard G. Grabenbauer ; MD ; PhD^a ; ^{gg@diacura.de" class="auth_mail" title="E-mail the corresponding author} (Professor of Radiation Oncology ; Head of the Department of Radiation Oncology) ; Gö ; bel Holger ; MD^b (Head of the Department of Gastroenterology)
• 关键词：Gastrointestinal cancer ; Supportive care ; Mucositis ; Diarrhoea ; Nutrition ; Enteral ; Parenteral ; Nausea ; Vomiting ; Antiemetics
• 刊名：Best Practice & Research Clinical Gastroenterology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：30
• 期：4
• 页码：655-664
• 全文大小：875 K

文摘

Possible toxic effects following radiation and chemotherapy of gastrointestinal tumours may cause a depletion of the mucosal barrier within the radiation volumes with severe mucositis. Diarrhoea, nausea, emesis and severe malabsorption followed by infections with dehydration and electrolyte disorders have to be encountered. For prevention and treatment of oropharyngeal mucositis an oral care protocol, oral cryotherapy together with benzydamine mouthwash may be recommended. Lower gastrointestinal diarrhoea is best treated by Octreotide (>100 μg s.c. bid) if loperamide is ineffective and amifostine (340 mg/m² IV) to prevent radiation proctitis.

Enteral nutrition may be necessary with severe malnutrition or no enteral food intake for >7days or insufficient intake (<60%) for >10 days. With severe generalized mucositis or severe radiation induced enteritis parenteral nutrition will be initiated. Following the application of highly emetogenic chemotherapy regimen, 5-HT3 antagonists, dexamethasone and aprepitant, whereas in moderate risk levels 5-HT3 antagonist plus dexamethasone may be sufficient.