Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission
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- 作者：Seong Joo Koo1 ; 4 ; Gaga Kochlamazashvili1 ; 4 ; Benjamin Rost3 ; Dmytro Puchkov1 ; Niclas Gimber1 ; Martin Lehmann1 ; 2 ; Georgi Tadeus1 ; Jan Schmoranzer1 ; 2 ; Christian Rosenmund3 ; Volker Haucke1 ; 2 ; 3 ; haucke@fmp-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Tanja Maritzen1 ; maritzen@fmp-berlin.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2015
- 出版时间：21 October 2015
- 年：2015
- 卷：88
- 期：2
- 页码：330-344
- 全文大小：4654 K
文摘
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Loss of the endocytic protein AP180 impairs neurotransmission and viability
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AP180 KO mice display excitatory/inhibitory imbalance and epileptic seizures
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Neurotransmission requires a large vesicular pool of Syb2 maintained by AP180