Poly(l-histidine) based copolymers: Effect of the chemically substituted l-histidine on the physio-chemical properties of the micelles and in vivo biodistribution
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- 作者：Xiaojun Zhang ; Dawei Chen ; Shuang Ba ; Jing Chang ; Jiaying Zhou ; Haixia Zhao ; Jia Zhu ; Xiuli Zhao ; Haiyang Hu ; Mingxi Qiao ; qiaomingxi@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：pH-sensitive ; Micelles ; Doxorubicin ; Chemical substitution ; l-histidine
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：176-184
- 全文大小：2393 K
文摘
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DNP group substituted class="smallcaps">L-histidine could not affect pH sensitivity of the copolymers.
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DNP group substituted copolymer could improve drug loading and stability of micelles.
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DNP group substituted copolymer could improve cellular uptake of micelles.
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Sturated nitrogen of PHis may serve as a valuable site for chemical modification.