A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis
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- 作者：Giuseppina Claps1 ; Yann Cheli1 ; Tongwu Zhang2 ; Marzia Scortegagna1 ; Eric Lau1 ; Hyungsoo Kim1 ; Jianfei Qi1 ; Jian-Liang Li1 ; Brian James1 ; Andreas Dzung3 ; Mitchell P. Levesque3 ; Reinhard Dummer3 ; Nicholas K. Hayward4 ; Marcus Bosenberg5 ; Kevin M. Brown2 ; Ze&rsquo ; ev A. Ronai1 ; zeev@ronailab.net" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：31 May 2016
- 年：2016
- 卷：15
- 期：9
- 页码：1884-1892
- 全文大小：5311 K
文摘
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Transcriptionally inactive ATF2 (Atf2Δ8,9) induces pigmentation
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Atf2Δ8,9 induces melanoma in BrafV600E mice
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Genes implicated in immune cell recruitment and metastasis are induced by Atf2Δ8,9
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Human ATF2 splice variant 5 phenocopies Atf2Δ8,9 and coincides with poor prognosis