Nanomedicines for endothelial disorders
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- 作者：Bomy Lee Chunga ; b ; 1Author Vitae ; Michael J. Tothc ; 1Author Vitae ; Nazila Kamalya ; dAuthor Vitae ; Yoshitaka J. Seic ; eAuthor Vitae ; Jacob BecraftfAuthor Vitae ; Willem J.M. MuldergAuthor Vitae ; Zahi A. FayadgAuthor Vitae ; Omid C. Farokhzadd ; hAuthor Vitae ; YongTae Kimc ; e ; i ; j ; ytkim@gatech.edu" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Robert Langera ; b ; f ; k ; rlanger@mit.edu" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Endothelium ; Nanomedicine ; Endothelial disorder ; Diabetes ; Atherosclerosis ; Cancer
- 刊名：Nano Today
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：10
- 期：6
- 页码：759-776
- 全文大小：3263 K
文摘
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We review the key features of a functioning and a malfunctioning endothelium.
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We highlight endothelial pathologies in asthma, burns, heart failure, and more.
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We discuss overlapping pathologies between diabetes, atherosclerosis, and cancer.
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The VEGF pathway is a possible target for treating multiple endothelial disorders.
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Nanotechnology can provide safer treatments and better in vivo study validations.