miR-431 is involved in regulating cochlear function by targeting Eya4
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- 作者：Yue Fana ; Ying Zhanga ; Rimao Wub ; Xingming Chena ; Yong Zhangb ; 1 ; dr_zhangyong@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiaowei Chena ; 1 ; chenxw_pumch@163.com" class="auth_mail" title="E-mail the corresponding author ; Dahai Zhub ;
- 关键词：miR-431 ; Eya4 ; Transgenic mouse ; Cochleae ; Spiral ganglion neuron
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：1862
- 期：11
- 页码：2119-2126
- 全文大小：1514 K
文摘
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miR-431 Tg mice exhibit hearing loss.
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SGN density is lower in cochleae of miR-431 Tg mice compared with Wt mice.
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SGNs in cultures from Tg mice are less numerous and their neurites are shorter.
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miR-431 directly targets Eya4 mRNA to regulate cochlear function.