Methylprednisolone sodium succinate reduces BBB disruption and inflammation in a model mouse of intracranial haemorrhage
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- 作者：Shiqi Chenga ; 1 ; WeiWei Gaob ; 1 ; Xin Xub ; 1 ; Hengyi Fana ; Yingang Wub ; Fei Lib ; Jianning Zhangb ; Xingen Zhua ; zhuxingen2008@163.com" class="auth_mail" title="E-mail the corresponding author ; Yan Zhanga ; doctorzhangyan@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BBB ; blood-brain barrier ; EB ; Evans Blue ; ICH ; intracranial haemorrhage ; IL-1β ; interleukin 1β ; MPSS ; methylprednisolone sodium succinate ; NF-κB ; nuclear factor κB ; TNF-α ; tumour necrosis factor α ; TLR4 ; toll-like receptor 4 ; ZO-1 ; zonula occludens 1
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：226-233
- 全文大小：2653 K
文摘
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MPSS treatment after ICH reduces BBB disruption and brain oedema.
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MPSS also inhibits production of inflammatory cytokines and inflammation in the brain.
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MPSS reduces apoptosis in the brain, perhaps by decreasing Bax and increasing Bcl-2.
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This suggests that MPSS may be a useful treatment for ICH and result in improved patient prognosis.