Brain and cord myelin water imaging: a progressive multiple sclerosis biomarker
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- 作者：Shannon Kolinda ; shannon.kolind@ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Arshia Seddighb ; Anna Combesc ; Bretta Russell-Schulzd ; Roger Tamd ; Vignan Yogendrakumara ; Sean Deonie ; f ; Naomi A. Sibtainb ; Anthony Traboulseea ; Steven C.R. Williamsc ; Gareth J. Barkerc ; 1 ; Peter A. Brexb ; 1
- 关键词：CCV ; cervical cord volume ; CSF ; cerebrospinal fluid ; EDSS ; Expanded Disability Status Scale ; FOV ; field of view ; mcDESPOT ; Multi-component driven equilibrium single pulse observation of T1 & T2 ; MR ; magnetic resonance ; MRI ; magnetic resonance imaging ; MS ; multiple sclerosis ; MSFC ; Multiple Sclerosis Functional Composite ; PASAT ; Paced Auditory Serial Addition Test ; PP ; primary progressive ; RR ; relapsing remitting ; SPGR ; spoiled gradient echo ; SSFP ; steady state free precession ; TE ; echo time ; TR
- 刊名：NeuroImage: Clinical
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：9
- 期：Complete
- 页码：574-580
- 全文大小：790 K
文摘
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A biomarker is needed to evaluate therapies for primary progressive MS (PPMS).
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We used novel MRI providing both general atrophy and specific myelin measures.
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We studied brain and cervical spinal cord in PPMS and healthy controls.
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Brain and spinal cord volume and myelin measures were reduced in PPMS vs controls.
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MRI measures described cognitive, fine motor and ambulatory disability scores.