Quantifying visual pathway axonal and myelin loss in multiple sclerosis and neuromyelitis optica
详细信息 查看全文
- 作者：Praveena Manogarana ; p.manogaran@alumni.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Irene M. Vavasourb ; lees@ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Alex P. Langec ; alex@lange.ch" class="auth_mail" title="E-mail the corresponding author ; Yinshan Zhaoa ; yinshan@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Katrina McMullena ; katrina.mcmullen@ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Alexander Rauscherd ; rauscher@phas.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Robert Carruthersa ; robert.carruthers@ubc.ca" class="auth_mail" title="E-mail the corresponding author ; David K.B. Lib ; david.li@ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Anthony L. Traboulseea ; t.traboulsee@ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Shannon H. Kolinda ; shannon.kolind@ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multiple sclerosis ; Neuromyelitis optica ; Optical coherence tomography ; Magnetic resonance imaging ; Myelin water imaging ; Optic neuritis
- 刊名：NeuroImage: Clinical
- 出版年：2016
- 出版时间：2016
- 年：2016
- 卷：11
- 期：Complete
- 页码：743-750
- 全文大小：805 K
文摘
- class="listitem" id="list_l0005">
- class="label">•
First study to assess relationship between segmented retinal layers and MRI in NMO
- class="label">•
First study to use optic radiation myelin water imaging in demyelinating diseases
- class="label">•
Inner nuclear layer thickening in MS with ON may occur independently of microcystic macular edema.
- class="label">•
Myelin density reduction in the optic radiation observed in demyelinating diseases
- class="label">•
Myelin loss may be due to subclinical MS disease activity in subjects without ON.
- class="label">•
ON may lead to retinal and optic radiation pathology via bidirectional degeneration.