Fabrication and characterization of a glucose-sensitive antibacterial chitosan-polyethylene oxide hydrogel
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- 作者：Yu Xiaoa ; b ; Tao Gongc ; Ying Jianga ; Yapin Wangb ; Zezhang T. Wenb ; Shaobing Zhouc ; shaobingzhou@swjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Chongyun Baoa ; cybao9933@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaoming Xub ; xxu@lsuhsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glucose-sensitive ; Hydrogel ; Chitosan ; Polyethylene oxide ; Controlled drug release ; Periodontitis
- 刊名：Polymer
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：82
- 期：Complete
- 页码：1-10
- 全文大小：2422 K
文摘
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A new glucose-sensitive chitosan–polyethylene oxide (CS–PEO) hydrogel system for controlled release of antibiotics was developed.
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The mechanical property and biocompatibility of the hydrogel was enhanced with increasing PEO concentration.
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This hydrogel showed higher drug release and greater ability to inhibit Porphyromonas gingivalis at higher glucose concentration.