Hepatobiliary phase images using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI as an imaging surrogate for the albumin-bilirubin grading system

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• 作者：Yasuo Takatsu ; Ph.D.^a ; ^b ; ^{pcblue2@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Satoshi Kobayashi ; MD Ph.D.^b ; ^{satoshik@staff.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Tosiaki Miyati ; Ph.D DMSc^b ; ^{ramiyati@mhs.mp.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Toshiki Shiozaki ; MD^a ; ^{shiozaki.toshiki@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Liver function ; Quantitative liver&ndash ; spleen contrast ratio ; Child&ndash ; Pugh score ; Albumin&ndash ; bilirubin grade ; Gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid
• 刊名：European Journal of Radiology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：85
• 期：12
• 页码：2206-2210
• 全文大小：762 K

文摘

To clarify the correlation between hepatobiliary phase (HBP) images using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) and albumin–bilirubin (ALBI) grading system.

Materials and methods

We evaluated 220 consecutive patients who underwent liver magnetic resonance imaging with Gd-EOB-DTPA. Quantitative liver–spleen contrast ratio (Q-LSC) was calculated in HBP images approximately 20 min after Gd-EOB-DTPA administration. To evaluate the degree of association between Q-LSC and ALBI grade, the Child–Pugh (C-P) score was used for comparison. Correlation coefficients were calculated, and median Q-LSC values were compared with the C-P scores and ALBI grades. The Steel–Dwass multiple comparison test was used for statistical analysis.

Results

The correlation coefficient between Q-LSC and C-P score was −0.35, P < 0.0001, and the ALBI grade was −0.61, P < 0.0001. Q-LSC of overall median, C-P A, B, and C were 1.94, 1.91, 1.96, and 1.33, respectively. The differences between C-P A and C-P B, C-P B and C-P C, and C-P A and C-P C were P = 0.999, 0.126, and 0.149, respectively. Q-LSC of the overall median, ALBI grade 1, 2, and 3 were 1.94, 2.12, 1.69, and 1.30, respectively. The differences between ALBI grades 1 and 2, 2 and 3, and 1 and 3 were P < 0.0001, P = 0.0466, and P = 0.0035, respectively. Q-LSC was better correlated and discriminated by ALBI grade than C-P score.

Conclusion

A strong correlation was observed between Q-LSC of an HBP image with Gd-EOB-DTPA and ALBI grade; HBP imaging could be a surrogate for the ALBI grade.