LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes
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- 作者：Peter Draber1 ; 3 ; Sebastian Kupka1 ; 3 ; Matthias Reichert1 ; 3 ; Helena Draberova1 ; Elodie Lafont1 ; Diego de Miguel1 ; Lisanne Spilgies1 ; Silvia Surinova1 ; Lucia Taraborrelli1 ; Torsten Hartwig1 ; Eva Rieser1 ; Luigi Martino2 ; Katrin Rittinger2 ; Henning Walczak1 ; h.walczak@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：13
- 期：10
- 页码：2258-2272
- 全文大小：4194 K
文摘
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LUBAC directly recruits CYLD to the TNFR1 complex where it antagonizes M1 linkages
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M1-ubiquitin chains recruit A20, which, in turn, protects them from degradation
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CYLD and A20 inhibit gene activation but oppose each other in regulating cell death
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OTULIN controls LUBAC activity prior to stimulation but not in signaling complexes