Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding
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- 作者：Ida Bjö ; rkgrena ; b ; 1 ; Luis Alvarezc ; Nelli Blankd ; Melanie Balbachd ; Heikki Turunena ; b ; Teemu Daniel Laajalae ; f ; Jussi Toivanena ; Anton Krutskikhg ; Niklas Wahlbergh ; Ilpo Huhtaniemig ; Matti Poutanena ; i ; Dagmar Wachtend ; Petra Sipilä ; a ; petra.sipila@utu.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Beta-defensin ; Epididymis ; Sperm maturation ; Flagellar motility pattern ; Sperm-oocyte binding ; iCre knock-in
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：427
- 期：Complete
- 页码：143-154
- 全文大小：1536 K
文摘
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Defb41iCre/+ knock-in mice can be used to make genetic modifications in the principal cells of proximal epididymis.
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Lack of Defb41 causes a defect in sperm motility.
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Lack of Defb41 causes sperm flagella primarily to bend in the pro-hook conformation in capacitated sperm.
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A change in flagellar binding pattern leads to a reduced straight line motility.