Establishment of drug delivery system nanocapsulated with an antioxidant (+)-catechin hydrate and sodium meta borate chelator against sodium fluoride induced oxidative stress in rats
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- 作者：Arpita Samantaa ; arpita.pari@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Soumen Chandab ; s.bt.chanda@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Bidyut Bandyopadhyaya ; bidyut2006@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Nirmalendu Dasc ; dasnirmalendu@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ROS ; reactive oxygen species ; NaF ; sodium fluoride ; H2O2 ; hydrogen peroxide ; ATP ; adenosine tri phosphate ; ADP ; adenosine di phosphate ; CH ; catechin hydrate ; SMB ; sodium meta borate ; NP ; nanoparticle ; NPCH ; nanoparticulatecatechin hydrate ; NPSMB ; nanoparticulate sodium meta borate ; NP (CH ; + ; SMB) ; nanoparticle encapsulated with catechin hydrate and sodium meta borate ; ICDH ; isocitrate dehydrogenase ; SDH ; succinate dehydrogenase ; MDH ; malate dehydrogenase ; αKGDH ; alpha ketoglutarate dehy
- 刊名：Journal of Trace Elements in Medicine and Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：54-67
- 全文大小：5290 K
文摘
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Simple antioxidant therapy is not enough to prevent the huge amount by peroxidised lipid generated by the induction of fluoride ion.
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Combined therapy both includes an antioxidant catechin hydrate and fluoride scavenger sodium metaborate in nanocapsulated drug delivery system could provide a complete protection against fluoride induced fluorosis.